MOUNTAINS 2020

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MOUNTAIN
RESEARCH
CENTER

O Norte Somos Nós

CIMO is the winner of the "O Norte Somos Nós" Awards in
the category of Research. See video HERE

MOUNTAIN
RESEARCH
CENTER

See a short video
about us

MOUNTAIN
RESEARCH
CENTER

Polytechnic Institute
of Bragança

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FROM NATURE TO PRODUCTS, TOWARDS SUSTAINABILITY.

Manuel Ricardo Costa Calhelha

Main Researcher
Group: Sustainable Processes and Products
Phone: 273330916
E-mail: calhelha@ipb.pt
ORCID: 0000-0002-6801-4578
Scopus Author ID: 6507978333

Career

  • Since 2019: Assistant at CIMO-IPB, Portugal
  • 2017 - 2019: Pos-Doc researcher in the project “Propriedades químicas e bioativas de produtos naturais obtidos a partir de matrizes vegetais e micológicas do Nordeste Transmontano”
  • 2011 - 2016: Pos-doc Researcher (SFRH/BPD/68344/2010)

Qualifications

  • 2010 - PhD. in Sciences, specialty in chemistry, University of Minho Minho, Braga, Portugal
  • 2003 - First degree in Biotechnological engineering, Polytechnic Institute of Bragança, Portugal

Interests

  • Antitumor activity of natural extracts (especially mushrooms and aromatic and medicinal plants) using human tumor cell lines
  • Establishment of primary cell cultures from normal cells as toxicity models
  • Anti-inflammatory activity of natural extracts using macrophages
  • Flow cytometry

Projects:

MAGLIDUO - MAGnetoLIposomes for DUal cancer therapy
Funding body: POCI-FEDER/FCT
Reference: POCI-01-0145-FEDER-028020
Principal Investigator:Lillian Bouçada de Barros
Start: 2018-06-01
End: 2021-06-30
IBERPHENOL - Red cooperativa de investigación en el ámbito de polifenoles y sus aplicaciones industriales
Funding body: POCTEP – Programa de Cooperação Transfronteiriça Portugal – Espanha
Reference:
Principal Investigator:Lillian Bouçada de Barros
Start: 2015-10-01
End: 2020-12-31

Total results: 198
1
Fernandes Â.,Bancessi A.,Pinela J.,Dias M.I.,Liberal Â.,Calhelha R.C.,Ćirić A.,Soković M.,Catarino L.,Ferreira I.C.F.R.,Barros L.
Nutritional and phytochemical profiles and biological activities of Moringa oleifera Lam. edible parts from Guinea-Bissau (West Africa)
Food Chemistry, 341, , 2021

2
Gómez-Mejía E.,Roriz C.L.,Heleno S.A.,Calhelha R.,Dias M.I.,Pinela J.,Rosales-Conrado N.,León-González M.E.,Ferreira I.C.F.R.,Barros L.
Valorisation of black mulberry and grape seeds: Chemical characterization and bioactive potential
Food Chemistry, 337, , 2021

3
Pires T.C.S.P.,Inês Dias M.,Calhelha R.C.,José Alves M.,Santos-Buelga C.,Ferreira I.C.F.R.,Barros L.
Development of new bilberry (Vaccinium myrtillus L.) based snacks: Nutritional, chemical and bioactive features
Food Chemistry, 334, , 2021

4
Pereira E.,Cadavez V.,Barros L.,Encina-Zelada C.,Stojković D.,Sokovic M.,Calhelha R.C.,Gonzales-Barron U.,Ferreira I.C.F.R.
Chenopodium quinoa Willd. (quinoa) grains: A good source of phenolic compounds
Food Research International, 137, , 2020

5
Finimundy T.C.,Karkanis A.,Fernandes Â.,Petropoulos S.A.,Calhelha R.,Petrović J.,Soković M.,Rosa E.,Barros L.,Ferreira I.C.F.R.
Bioactive properties of Sanguisorba minor L. cultivated in central Greece under different fertilization regimes
Food Chemistry, 327, , 2020

6
Petropoulos S.A.,Fernandes Â.,Plexida S.,Pereira C.,Dias M.I.,Calhelha R.,Chrysargyris A.,Tzortzakis N.,Petrović J.,Soković M.D.,Ferreira I.C.F.R.,Barros L.
The sustainable use of cotton, hazelnut and ground peanut waste in vegetable crop production
Sustainability (Switzerland), 12, 1-17, 2020

7
Kostić M.,Ivanov M.,Fernandes Â.,Pinela J.,Calhelha R.C.,Glamočlija J.,Barros L.,Ferreira I.C.F.R.,Soković M.,Ćirić A.
Antioxidant extracts of three russula genus species express diverse biological activity
Molecules, 25, , 2020

8
Ziani B.E.C.,Carocho M.,Abreu R.M.V.,Bachari K.,Alves M.J.,Calhelha R.C.,Talhi O.,Barros L.,Ferreira I.C.F.R.
Phenolic profiling, biological activities and in silico studies of Acacia tortilis (Forssk.) Hayne ssp. raddiana extracts
Food Bioscience, 36, , 2020

9
Madureira J.,Dias M.I.,Pinela J.,Calhelha R.C.,Barros L.,Santos-Buelga C.,Margaça F.M.A.,Ferreira I.C.F.R.,Cabo Verde S.
The use of gamma radiation for extractability improvement of bioactive compounds in olive oil wastes
Science of the Total Environment, 727, , 2020

10
Spréa R.M.,Fernandes Â.,Finimundy T.C.,Pereira C.,Alves M.J.,Calhelha R.C.,Canan C.,Barros L.,Amaral J.S.,Ferreira I.C.F.R.
Lovage (Levisticum officinale W.D.J. Koch) roots: A source of bioactive compounds towards a circular economy
Resources, 9, , 2020

11
Ghada B.,Pereira E.,Pinela J.,Prieto M.A.,Pereira C.,Calhelha R.C.,Stojkovic D.,Sokóvic M.,Zaghdoudi K.,Barros L.,Ferreira I.C.F.R.
Recovery of anthocyanins from passion fruit epicarp for food colorants: Extraction process optimization and evaluation of bioactive properties
Molecules, 25, , 2020

12
Vieira V.,Calhelha R.C.,Barros L.,Coutinho J.A.P.,Ferreira I.C.F.R.,Ferreira O.
Insights on the extraction performance of alkanediols and glycerol: Using Juglans regia L. Leaves as a source of bioactive compounds
Molecules, 25, , 2020

13
Coelho J.,Barros L.,Dias M.I.,Finimundy T.C.,Amaral J.S.,Alves M.J.,Calhelha R.C.,Santos P.F.,Ferreira I.C.F.R.
Echinacea purpurea (L.) moench: Chemical characterization and bioactivity of its extracts and fractions
Pharmaceuticals, 13, 1-16, 2020

14
Pinela J.,Omarini A.B.,Stojković D.,Barros L.,Postemsky P.D.,Calhelha R.C.,Breccia J.,Fernández-Lahore M.,Soković M.,Ferreira I.C.F.R.
Biotransformation of rice and sunflower side-streams by dikaryotic and monokaryotic strains of Pleurotus sapidus: Impact on phenolic profiles and bioactive properties
Food Research International, 132, , 2020

15
Ayuso M.,Pinela J.,Dias M.I.,Barros L.,Ivanov M.,Calhelha R.C.,Soković M.,Ramil-Rego P.,Barreal M.E.,Gallego P.P.,Ferreira I.C.F.R.
Phenolic composition and biological activities of the in vitro cultured endangered Eryngium viviparum J. Gay
Industrial Crops and Products, 148, , 2020

16
17
Gonzales-Barron U.,Dijkshoorn R.,Maloncy M.,Finimundy T.,Calhelha R.C.,Pereira C.,Stojković D.,Soković M.,Ferreira I.C.F.R.,Barros L.,Cadavez V.
Nutritive and bioactive properties of mesquite (prosopis pallida) flour and its technological performance in breadmaking
Foods, 9, , 2020

18
Petropoulos S.A.,Fernandes Â.,Dias M.I.,Pereira C.,Calhelha R.C.,Chrysargyris A.,Tzortzakis N.,Ivanov M.,Sokovic M.D.,Barros L.,Ferreira I.C.F.R.
Chemical composition and plant growth of Centaurea raphanina subsp. mixta plants cultivated under saline conditions
Molecules, 25, , 2020

19
Finimundy T.C.,Pereira C.,Dias M.I.,Caleja C.,Calhelha R.C.,Sokovic M.,Stojković D.,Carvalho A.M.,Rosa E.,Barros L.,Ferreira I.C.F.R.
Infusions of herbal blends as promising sources of phenolic compounds and bioactive properties
Molecules, 25, , 2020

20
Sampaio S.L.,Fernandes Â.,Pereira C.,Calhelha R.C.,Sokovic M.,Santos-Buelga C.,Barros L.,Ferreira I.C.F.R.
Nutritional value, physicochemical characterization and bioactive properties of the Brazilian quinoa: BRS Piabiru
Food and Function, 11, 2969-2977, 2020

21
Majdi C.,Pereira C.,Dias M.I.,Calhelha R.C.,Alves M.J.,Frih B.,Charrouf Z.,Barros L.,Amaral J.S.,Ferreira I.C.F.R.
Phytochemical characterization and bioactive properties of cinnamon basil (Ocimum basilicum cv. ‘cinnamon’) and lemon basil (ocimum x citriodorum)
Antioxidants, 9, , 2020

22
Petropoulos S.A.,Fernandes Â.,Dias M.I.,Pereira C.,Calhelha R.,Di Gioia F.,Tzortzakis N.,Ivanov M.,Sokovic M.,Barros L.,Ferreira I.C.F.R.
Wild and cultivated centaurea raphanina subsp. Mixta: A valuable source of bioactive compounds
Antioxidants, 9, , 2020

23
Albuquerque B.R.,Pereira C.,Calhelha R.C.,José Alves M.,Abreu R.M.V.,Barros L.,Oliveira M.B.P.P.,Ferreira I.C.F.R.
Jabuticaba residues (Myrciaria jaboticaba (Vell.) Berg) are rich sources of valuable compounds with bioactive properties
Food Chemistry, 309, , 2020

24
Caleja C.,Barros L.,Barreira J.C.M.,Soković M.,Calhelha R.C.,Bento A.,Oliveira M.B.P.P.,Ferreira I.C.F.R.
Castanea sativa male flower extracts as an alternative additive in the Portuguese pastry delicacy "pastel de nata"
Food and Function, 11, 2208-2217, 2020

25
Vieira V.,Pereira C.,Abreu R.M.V.,Calhelha R.C.,Alves M.J.,Coutinho J.A.P.,Ferreira O.,Barros L.,Ferreira I.C.F.R.
Hydroethanolic extract of Juglans regia L. green husks: A source of bioactive phytochemicals
Food and Chemical Toxicology, 137, , 2020

26
Silva A.R.,Pinela J.,Dias M.I.,Calhelha R.C.,Alves M.J.,Mocan A.,García P.A.,Barros L.,Ferreira I.C.F.R.
Exploring the phytochemical profile of Cytinus hypocistis (L.) L. as a source of health-promoting biomolecules behind its in vitro bioactive and enzyme inhibitory properties
Food and Chemical Toxicology, 136, , 2020

27
Spréa R.M.,Fernandes Â.,Calhelha R.C.,Pereira C.,Pires T.C.S.P.,Alves M.J.,Canan C.,Barros L.,Amaral J.S.,Ferreira I.C.F.R.
Chemical and bioactive characterization of the aromatic plant: Levisticum officinale W.D.J. Koch: a comprehensive study
Food and Function, 11, 1292-1303, 2020

28
Lageiro M.M.,Castanho A.,Pereira C.,Calhelha R.C.,Ferreira I.C.F.R.,Brites C.
Assessment of gamma oryzanol variability, an attractive rice bran bioactive compound
Emirates Journal of Food and Agriculture, 32, 38-46, 2020

29
da Silva Veloso F.,Caleja C.,Calhelha R.C.,Pires T.C.S.,Alves M.J.,Barros L.,Genena A.K.,Barreira J.C.M.,Ferreira I.C.F.R.
Characterization and application of pomegranate epicarp extracts as functional ingredients in a typical Brazilian pastry product
Molecules, 25, , 2020

30
Conceição N.,Albuquerque B.R.,Pereira C.,Corrêa R.C.G.,Lopes C.B.,Calhelha R.C.,Alves M.J.,Barros L.,Ferreira I.C.F.R.
By-products of camu-camu [Myrciaria dubia (Kunth) McVaugh] as promising sources of bioactive high added-value food ingredients: Functionalization of yogurts
Molecules, 25, , 2020

31
Dias M.,Caleja C.,Pereira C.,Calhelha R.,Kostic M.,Sokovic M.,Tavares D.,Baraldi I.,Barros L.,Ferreira I.
Chemical composition and bioactive properties of byproducts from two different kiwi varieties
Food Research International, 127, , 2020

32
Graça V.C.,Calhelha R.C.,Nunes F.M.,Berthet J.,Ferreira I.C.F.R.,Santos P.F.
Isolation of secondary metabolites from Geranium molle L. with anticancer potential
Industrial Crops and Products, 142, , 2019

33
Pereira C.,Dias M.I.,Petropoulos S.A.,Plexida S.,Chrysargyris A.,Tzortzakis N.,Calhelha R.C.,Ivanov M.,Stojković D.,Soković M.,Barros L.,Ferreira I.C.F.R.
The effects of biostimulants, biofertilizers and water-stress on nutritional value and chemical composition of two spinach genotypes (Spinacia oleracea L.)
Molecules, 24, , 2019

34
Chihoub W.,Dias M.I.,Barros L.,Calhelha R.C.,Alves M.J.,Harzallah-Skhiri F.,Ferreira I.C.F.R.
Valorisation of the green waste parts from turnip, radish and wild cardoon: Nutritional value, phenolic profile and bioactivity evaluation
Food Research International, 126, , 2019

35
Petropoulos S.,Fernandes Â.,Calhelha R.,Di Gioia F.,Kolovou P.,Barros L.,Ferreira I.
Chemical composition and bioactive properties of Cichorium spinosum L. in relation to nitrate/ammonium nitrogen ratio
Journal of the Science of Food and Agriculture, 99, 6741-6750, 2019

36
Ćirić A.,Kruljević I.,Stojković D.,Fernandes Â.,Barros L.,Calhelha R.C.,Ferreira I.C.F.R.,Soković M.,Glamočlija J.
Comparative investigation on edible mushrooms Macrolepiota mastoidea, M. rhacodes and M. procera: Functional foods with diverse biological activities
Food and Function, 10, 7678-7686, 2019

37
Afonso A.F.,Pereira O.R.,Fernandes Â.,Calhelha R.C.,Silva A.M.S.,Ferreira R.C.F.,Cardoso S.M.
Phytochemical composition and bioactive effects of Salvia africana, salvia officinalis 'Icterina' and Salvia mexicana aqueous Extracts
Molecules, 24, , 2019

38
Campestrini L.,Melo P.,Peres L.,Calhelha R.,Ferreira I.,Alencar S.
A new variety of purple tomato as a rich source of bioactive carotenoids and its potential health benefits
Heliyon, 5, , 2019

39
Harumi Iyda J.,Fernandes Â.,Calhelha R.C.,Alves M.J.,Ferreira F.D.,Barros L.,Amaral J.S.,Ferreira I.C.F.R.
Nutritional composition and bioactivity of Umbilicus rupestris (Salisb.)Dandy: An underexploited edible wild plant
Food Chemistry, 295, 341-349, 2019

40
Garcia J.A.A.,Corrêa R.C.G.,Barros L.,Pereira C.,Abreu R.M.V.,Alves M.J.,Calhelha R.C.,Bracht A.,Peralta R.M.,Ferreira I.C.F.R.
Phytochemical profile and biological activities of 'Ora-pro-nobis' leaves (Pereskia aculeata Miller), an underexploited superfood from the Brazilian Atlantic Forest
Food Chemistry, 294, 302-308, 2019

41
Añibarro-Ortega M.,Pinela J.,Barros L.,Ćirić A.,Silva S.,Coelho E.,Mocan A.,Calhelha R.,Soković M.,Coimbra M.,Ferreira I.
Compositional features and bioactive properties of aloe vera leaf (Fillet, mucilage, and rind) and flower
Antioxidants, 8, , 2019

42
Arribas C.,Pereira E.,Barros L.,Alves M.,Calhelha R.,Guillamón E.,Pedrosa M.,Ferreira I.
Healthy novel gluten-free formulations based on beans, carob fruit and rice: Extrusion effect on organic acids, tocopherols, phenolic compounds and bioactivity
Food Chemistry, 292, 304-313, 2019

43
Rached W.,Barros L.,Ziani B.,Bennaceur M.,Calhelha R.,Heleno S.,Alves M.,Marouf A.,Ferreira I.
HPLC-DAD-ESI-MS/MS screening of phytochemical compounds and the bioactive properties of different plant parts of: Zizyphus lotus (L.) Desf.
Food and Function, 10, 5898-5909, 2019

44
Caleja C.,Finimundy T.,Pereira C.,Barros L.,Calhelha R.,Sokovic M.,Ivanov M.,Carvalho A.,Rosa E.,Ferreira I.
Challenges of traditional herbal teas: Plant infusions and their mixtures with bioactive properties
Food and Function, 10, 5939-5951, 2019

45
da Silva S.C.,Fernandes I.P.,Barros L.,Fernandes Â.,José Alves M.,Calhelha R.C.,Pereira C.,Barreira J.C.M.,Manrique Y.,Colla E.,Ferreira I.C.F.R.,Filomena Barreiro M.
Spray-dried Spirulina platensis as an effective ingredient to improve yogurt formulations: Testing different encapsulating solutions
Journal of Functional Foods, 60, , 2019

46
Pereira D.S.M.,Cardoso B.D.,Rodrigues A.R.O.,Amorim C.O.,Amaral V.S.,Almeida B.G.,Queiroz M.J.R.P.,Martinho O.,Baltazar F.,Calhelha R.C.,Ferreira I.C.F.R.,Coutinho P.J.G.,Castanheira E.M.S.
Magnetoliposomes containing calcium ferrite nanoparticles for applications in breast cancer therapy
Pharmaceutics, 11, , 2019

47
Falcão S.I.,Calhelha R.C.,Touzani S.,Lyoussi B.,Ferreira I.C.F.R.,Vilas-Boas M.
In vitro interactions of moroccan propolis phytochemical’s on human tumor cell lines and anti-inflammatory properties
Biomolecules, 9, , 2019

48
Afonso A.,Pereira O.,Fernandes Â.,Calhelha R.,Silva A.,Ferreira I.,Cardoso S.
The health-benefits and phytochemical profile of salvia apiana and salvia farinacea var. Victoria blue decoctions
Antioxidants, 8, , 2019

49
Vieira V.,Pereira C.,Pires T.,Calhelha R.,Alves M.,Ferreira O.,Barros L.,Ferreira I.
Phenolic profile, antioxidant and antibacterial properties of Juglans regia L. (walnut) leaves from the Northeast of Portugal
Industrial Crops and Products, 134, 347-355, 2019

50
Alonso-Esteban J.,Pinela J.,Barros L.,Ćirić A.,Soković M.,Calhelha R.,Torija-Isasa E.,de Cortes Sánchez-Mata M.,Ferreira I.
Phenolic composition and antioxidant, antimicrobial and cytotoxic properties of hop (Humulus lupulus L.) Seeds
Industrial Crops and Products, 134, 154-159, 2019

51
Da Silva L.,Pereira E.,Prieto M.,Simal-Gandara J.,Pires T.,Alves M.,Calhelha R.,Barros L.,Ferreira I.
Rubus ulmifolius Schott as a Novel Source of Food Colorant: Extraction optimization of coloring pigments and incorporation in a bakery product
Molecules, 24, , 2019

52
Fernandes F.,Pereira E.,Círić A.,Soković M.,Calhelha R.,Barros L.,Ferreira I.
Ocimum basilicum var. Purpurascens leaves (red rubin basil): A source of bioactive compounds and natural pigments for the food industry
Food and Function, 10, 3161-3171, 2019

53
Taofiq O.,Heleno S.A.,Calhelha R.C.,Fernandes I.P.,Alves M.J.,Barros L.,González-Paramás A.M.,Ferreira I.C.F.R.,Barreiro M.F.
Phenolic acids, cinnamic acid, and ergosterol as cosmeceutical ingredients: Stabilization by microencapsulation to ensure sustained bioactivity
Microchemical Journal, 147, 469-477, 2019

54
Castanho A.,Lageiro M.,Calhelha R.C.,Ferreira I.C.F.R.,Sokovic M.,Cunha L.M.,Brites C.
Exploiting the bioactive properties of γ-oryzanol from bran of different exotic rice varieties
Food and Function, 10, 2382-2389, 2019

55
Chahdoura H.,Barreira J.C.M.,Barros L.,Dias M.I.,Calhelha R.C.,Flamini G.,Soković M.,Achour L.,Ferreira I.C.F.R.
Bioactivity, hydrophilic, lipophilic and volatile compounds in pulps and skins of Opuntia macrorhiza and Opuntia microdasys fruits
LWT, 105, 57-65, 2019

56
Pinho E.,Calhelha R.,Ferreira I.,Soares G.
Cotton-hydrogel composite for improved wound healing: Antimicrobial activity and anti-inflammatory evaluation—Part 2
Polymers for Advanced Technologies, 30, 863-871, 2019

57
Jabeur I.,Pereira E.,Caleja C.,Calhelha R.,Soković M.,Catarino L.,Barros L.,Ferreira I.
Exploring the chemical and bioactive properties of: Hibiscus sabdariffa L. calyces from Guinea-Bissau (West Africa)
Food and Function, 10, 2234-2243, 2019

58
Garcia J.,Corrêa R.,Barros L.,Pereira C.,Abreu R.,Alves M.,Calhelha R.,Bracht A.,Peralta R.,Ferreira I.
Chemical composition and biological activities of Juçara (Euterpe edulis Martius) fruit by-products, a promising underexploited source of high-added value compounds
Journal of Functional Foods, 55, 325-332, 2019

59
Souilem F.,Dias M.I.,Barros L.,Calhelha R.C.,Alves M.J.,Harzallah-Skhiri F.,Ferreira I.C.F.R.
Amantagula Fruit (Carissa macrocarpa (Eckl.) A.DC.): Nutritional and Phytochemical Characterization
Plant Foods for Human Nutrition, 74, 76-82, 2019

60
López C.J.,Caleja C.,Prieto M.A.,Sokovic M.,Calhelha R.C.,Barros L.,Ferreira I.C.F.R.
Stability of a cyanidin-3-O-glucoside extract obtained from Arbutus unedo L. and incorporation into wafers for colouring purposes
Food Chemistry, 275, 426-438, 2019

61
Silva de Sá I.,Peron A.P.,Leimann F.V.,Bressan G.N.,Krum B.N.,Fachinetto R.,Pinela J.,Calhelha R.C.,Barreiro M.F.,Ferreira I.C.F.R.,Gonçalves O.H.,Ineu R.P.
In vitro and in vivo evaluation of enzymatic and antioxidant activity, cytotoxicity and genotoxicity of curcumin-loaded solid dispersions
Food and Chemical Toxicology, 125, 29-37, 2019

62
Fernandes F.,Pereira E.,Prieto M.,Calhelha R.,Ćirić A.,Soković M.,Simal-Gandara J.,Barros L.,Ferreira I.
Optimization of the Extraction Process to Obtain a Colorant Ingredient from Leaves of Ocimum basilicum var. Purpurascens
Molecules, 24, , 2019

63
Ziani B.E.C.,Rached W.,Bachari K.,Alves M.J.,Calhelha R.C.,Barros L.,Ferreira I.C.F.R.
Detailed chemical composition and functional properties of Ammodaucus leucotrichus Cross. & Dur. and Moringa oleifera Lamarck
Journal of Functional Foods, 53, 237-247, 2019

64
Dos Santos P.,Francisco C.,Coqueiro A.,Leimann F.,Pinela J.,Calhelha R.,Porto Ineu R.,Ferreira I.,Bona E.,Gonçalves O.
The nanoencapsulation of curcuminoids extracted from: Curcuma longa L. and an evaluation of their cytotoxic, enzymatic, antioxidant and anti-inflammatory activities
Food and Function, 10, 573-582, 2019

65
Lockowandt L.,Pinela J.,Roriz C.,Pereira C.,Abreu R.,Calhelha R.,Alves M.,Barros L.,Bredol M.,Ferreira I.
Chemical features and bioactivities of cornflower (Centaurea cyanus L.) capitula: The blue flowers and the unexplored non-edible part
Industrial Crops and Products, 128, 496-503, 2019

66
Gonçalves G.,Corrêa R.,Barros L.,Dias M.,Calhelha R.,Correa V.,Bracht A.,Peralta R.,Ferreira I.
Effects of in vitro gastrointestinal digestion and colonic fermentation on a rosemary (Rosmarinus officinalis L) extract rich in rosmarinic acid
Food Chemistry, 271, 393-400, 2019

67
Da Silva R.,Barreira J.,Heleno S.,Barros L.,Calhelha R.,Ferreira I.
Anthocyanin profile of elderberry juice: A natural-based bioactive colouring ingredient with potential food application
Molecules, 24, , 2019

68
Souilem F.,Dias M.I.,Barros L.,Calhelha R.C.,Alves M.J.,Harzallah-Skhiri F.,Ferreira I.C.F.R.
Phenolic profile and bioactive properties of carissa macrocarpa (Eckl.) A.DC.: An in vitro comparative study between leaves, stems, and flowers
Molecules, 24, , 2019

69
Mandim F.,Graça V.C.,Calhelha R.C.,Machado I.L.F.,Ferreira L.F.V.,Ferreira I.C.F.R.,Santos P.F.
Synthesis, photochemical and in vitro cytotoxic evaluation of new iodinated aminosquaraines as potential sensitizers for photodynamic therapy
Molecules, 24, , 2019

70
Magalhães Á.F.,Graça V.C.,Calhelha R.C.,Ferreira Machado I.L.,Vieira Ferreira L.F.,Ferreira I.C.F.R.,Santos P.F.
Synthesis, photochemical and in vitro cytotoxic evaluation of benzoselenazole-based aminosquaraines
Photochemical and Photobiological Sciences, 18, 336-342, 2019

71
Mandim F.,Barros L.,Calhelha R.,Abreu R.,Pinela J.,Alves M.,Heleno S.,Santos P.,Ferreira I.
Calluna vulgaris (L.) Hull: Chemical characterization, evaluation of its bioactive properties and effect on the vaginal microbiota
Food and Function, 10, 78-89, 2019

72
Rodrigues R.,Baldi G.,Doumett S.,Garcia-Hevia L.,Gallo J.,Bañobre-López M.,Dražić G.,Calhelha R.,Ferreira I.,Lima R.,Gomes H.,Silva A.
Multifunctional graphene-based magnetic nanocarriers for combined hyperthermia and dual stimuli-responsive drug delivery
Materials Science and Engineering C, 93, 206-217, 2018

73
Petropoulos S.,Fernandes Â.,Calhelha R.,Danalatos N.,Barros L.,Ferreira I.
How extraction method affects yield, fatty acids composition and bioactive properties of cardoon seed oil?
Industrial Crops and Products, 124, 459-465, 2018

74
Taofiq O.,Heleno S.A.,Calhelha R.C.,Fernandes I.P.,Alves M.J.,Barros L.,González-Paramás A.M.,Ferreira I.C.F.R.,Barreiro M.F.
Mushroom-based cosmeceutical ingredients: Microencapsulation and in vitro release profile
Industrial Crops and Products, 124, 44-52, 2018

75
Zan R.,Fernandes Â.,Jedoz S.,Oludemi T.,Calhelha R.,Pires T.,Alves M.,Martins R.,Barros L.,Ferreira I.
Bioactive properties and phytochemical assessment of Bacupari-anão (: Garcinia brasiliensis Mart.) leaves native to Rondônia, Brazil
Food and Function, 9, 5621-5628, 2018

76
Pires T.,Dias M.,Barros L.,Calhelha R.,Alves M.,Santos-Buelga C.,Ferreira I.
Phenolic compounds profile, nutritional compounds and bioactive properties of Lycium barbarum L.: A comparative study with stems and fruits
Industrial Crops and Products, 122, 574-581, 2018

77
Pereira E.,Pimenta A.,Barros L.,Calhelha R.,Antonio A.,Cabo Verde S.,Ferreira I.
Effects of gamma radiation on the bioactivity of medicinal and aromatic plants: Mentha × piperita L., Thymus vulgaris L. and Aloysia citrodora Paláu as case studies
Food and Function, 9, 5150-5161, 2018

78
Almeida H.H.S.,Barros L.,Barreira J.C.M.,Calhelha R.C.,Heleno S.A.,Sayer C.,Miranda C.G.,Leimann F.V.,Barreiro M.F.,Ferreira I.C.F.R.
Bioactive evaluation and application of different formulations of the natural colorant curcumin (E100) in a hydrophilic matrix (yogurt)
Food Chemistry, 261, 224-232, 2018

79
Ghouti D.,Rached W.,Abdallah M.,Pires T.,Calhelha R.,Alves M.,Abderrahmane L.,Barros L.,Ferreira I.
Phenolic profile and in vitro bioactive potential of Saharan Juniperus phoenicea L. and Cotula cinerea (Del) growing in Algeria
Food and Function, 9, 4664-4672, 2018

80
Halla N.,Heleno S.A.,Costa P.,Fernandes I.P.,Calhelha R.C.,Boucherit K.,Rodrigues A.E.,Ferreira I.C.F.R.,Barreiro M.F.
Chemical profile and bioactive properties of the essential oil isolated from Ammodaucus leucotrichus fruits growing in Sahara and its evaluation as a cosmeceutical ingredient
Industrial Crops and Products, 119, 249-254, 2018

81
Santos K.S.,Barbosa A.M.,Freitas V.,Muniz A.V.C.S.,Mendonça M.C.,Calhelha R.C.,Ferreira I.C.F.R.,Franceschi E.,Padilha F.F.,Oliveira M.B.P.P.,Dariva C.
Antiproliferative activity of neem leaf extracts obtained by a sequential pressurized liquid extraction
Pharmaceuticals, 11, , 2018

82
Nenadić M.,Soković M.,Calhelha R.,Ferreira I.,Ćirić A.,Vesović N.,Ćurčić S.
Inhibition of tumour and non-tumour cell proliferation by pygidial gland secretions of four ground beetle species (Coleoptera: Carabidae)
Biologia, 73, 787-792, 2018

83
Kungel P.,Correa V.,Corrêa R.,Peralta R.,Soković M.,Calhelha R.,Bracht A.,Ferreira I.
Antioxidant and antimicrobial activities of a purified polysaccharide from yerba mate (Ilex paraguariensis)
International Journal of Biological Macromolecules, 114, 1161-1167, 2018

84
Peixoto C.,Dias M.,Alves M.,Calhelha R.,Barros L.,Pinho S.,Ferreira I.
Grape pomace as a source of phenolic compounds and diverse bioactive properties
Food Chemistry, 253, 132-138, 2018

85
Rocha F.,Yumi Sugahara L.,Leimann F.V.,De Oliveira S.M.,Da Silva Brum E.,Calhelha R.C.,Barreiro M.F.,Ferreira I.C.F.R.,Porto Ineu R.,Gonçalves O.H.
Nanodispersions of beta-carotene: effects on antioxidant enzymes and cytotoxic properties
Food and Function, 9, 3698-3706, 2018

86
Caleja C.,Barros L.,Barreira J.C.M.,Ciric A.,Sokovic M.,Calhelha R.C.,Beatriz M.,Oliveira P.P.,Ferreira I.C.F.R.
Suitability of lemon balm (Melissa officinalis L.) extract rich in rosmarinic acid as a potential enhancer of functional properties in cupcakes
Food Chemistry, 250, 67-74, 2018

87
Francisco C.R.L.,Heleno S.A.,Fernandes I.P.M.,Barreira J.C.M.,Calhelha R.C.,Barros L.,Gonçalves O.H.,Ferreira I.C.F.R.,Barreiro M.F.
Functionalization of yogurts with Agaricus bisporus extracts encapsulated in spray-dried maltodextrin crosslinked with citric acid
Food Chemistry, 245, 845-853, 2018

88
Finimundy T.,Barros L.,Calhelha R.,Alves M.,Prieto M.,Abreu R.,Dillon A.,Henriques J.,Roesch-Ely M.,Ferreira I.
Multifunctions of Pleurotus sajor-caju (Fr.) Singer: A highly nutritious food and a source for bioactive compounds
Food Chemistry, 245, 150-158, 2018

89
Graça V.,Dias M.,Barros L.,Calhelha R.,Santos P.,Ferreira I.
Fractionation of the more active extracts of: Geranium molle L.: A relationship between their phenolic profile and biological activity
Food and Function, 9, 2032-2042, 2018

90
Petrova K.,Barros M.,Calhelha R.,Soković M.,Ferreira I.
Antimicrobial and cytotoxic activities of short carbon chain unsaturated sucrose esters
Medicinal Chemistry Research, 27, 980-988, 2018

91
Pires T.,Dias M.,Barros L.,Calhelha R.,Alves M.,Oliveira M.,Santos-Buelga C.,Ferreira I.
Edible flowers as sources of phenolic compounds with bioactive potential
Food Research International, 105, 580-588, 2018

92
Adouni K.,Chahdoura H.,Mosbah H.,Santos-Buelga C.,González-Paramás A.M.,Ciudad-Mulero M.,Fernandes Â.,Calhelha R.C.,Morales P.,Flamini G.,Ferreira I.C.F.R.,Achour L.
Revalorization of wild: Asparagus stipularis Forssk. as a traditional vegetable with nutritional and functional properties
Food and Function, 9, 1578-1586, 2018

93
94
Smiljkovic M.,Matsoukas M.T.,Kritsi E.,Zelenko U.,Grdadolnik S.G.,Calhelha R.C.,Ferreira I.C.F.R.,Sankovic-Babic S.,Glamoclija J.,Fotopoulou T.,Koufaki M.,Zoumpoulakis P.,Sokovic M.
Nitrate Esters of Heteroaromatic Compounds as Candida albicans CYP51 Enzyme Inhibitors
ChemMedChem, 13, 251-258, 2018

95
Rached W.,Zeghada F.,Bennaceur M.,Barros L.,Calhelha R.,Heleno S.,Alves M.,Carvalho A.,Marouf A.,Ferreira I.
Phytochemical analysis and assessment of antioxidant, antimicrobial, anti-inflammatory and cytotoxic properties of Tetraclinis articulata (Vahl) Masters leaves
Industrial Crops and Products, 112, 460-466, 2018

96
Rashed K.,Ćirič A.,Glamočlija J.,Calhelha R.,Ferreira I.,Soković M.
Identification of the bioactive constituents and the antibacterial, antifungal and cytotoxic activities of different fractions from Cestrum nocturnum L.
Jordan Journal of Biological Sciences, 11, 273-279, 2018

97
Lopes C.,Pereira E.,Soković M.,Carvalho A.,Barata A.,Lopes V.,Rocha F.,Calhelha R.,Barros L.,Ferreira I.
Phenolic Composition and Bioactivity of Lavandula pedunculata (Mill.) Cav. Samples from Different Geographical Origin
Molecules, 23, , 2018

98
Graça V.,Barros L.,Calhelha R.,Dias M.,Ferreira I.,Santos P.
Bio-guided fractionation of extracts of Geranium robertianum L.: Relationship between phenolic profile and biological activity
Industrial Crops and Products, 108, 543-552, 2017

99
100
Oliveira F.S.,Ribeiro A.,Barros L.,Calhelha R.C.,Barreira J.C.M.,Junior B.D.,Abreu R.M.V.,Barreiro M.F.,Ferreira I.C.F.R.
Evaluation of Arenaria montana L. hydroethanolic extract as a chemopreventive food ingredient: A case study focusing a dairy product (yogurt)
Journal of Functional Foods, 38, 214-220, 2017

101
Jabeur I.,Pereira E.,Barros L.,Calhelha R.C.,Soković M.,Oliveira M.B.P.P.,Ferreira I.C.F.R.
Hibiscus sabdariffa L. as a source of nutrients, bioactive compounds and colouring agents
Food Research International, 100, 717-723, 2017

102
Taofiq O.,Heleno S.A.,Calhelha R.C.,Alves M.J.,Barros L.,González-Paramás A.M.,Barreiro M.F.,Ferreira I.C.F.R.
The potential of Ganoderma lucidum extracts as bioactive ingredients in topical formulations, beyond its nutritional benefits
Food and Chemical Toxicology, 108, 139-147, 2017

103
Souilem F.,Fernandes Â.,Calhelha R.C.,Barreira J.C.M.,Barros L.,Skhiri F.,Martins A.,Ferreira I.C.F.R.
Wild mushrooms and their mycelia as sources of bioactive compounds: Antioxidant, anti-inflammatory and cytotoxic properties
Food Chemistry, 230, 40-48, 2017

104
Rached W.,Bennaceur M.,Barros L.,Calhelha R.,Heleno S.,Alves M.,Carvalho A.,Marouf A.,Ferreira I.
Detailed phytochemical characterization and bioactive properties of: Myrtus nivelii Batt & Trab
Food and Function, 8, 3111-3119, 2017

105
Corrêa R.,Haminiuk C.,Barros L.,Dias M.,Calhelha R.,Kato C.,Correa V.,Peralta R.,Ferreira I.
Stability and biological activity of Merlot (Vitis vinifera) grape pomace phytochemicals after simulated in vitro gastrointestinal digestion and colonic fermentation
Journal of Functional Foods, 36, 410-417, 2017

106
Chahdoura H.,Barreira J.C.M.,Adouni K.,Mhadhebi L.,Calhelha R.C.,Snoussi M.,Majdoub H.,Flamini G.,Ferreira I.C.F.R.,Achour L.
Bioactivity and chemical characterization of: Opuntia macrorhiza Engelm. seed oil: Potential food and pharmaceutical applications
Food and Function, 8, 2739-2747, 2017

107
Cardoso R.,Fernandes Â.,Oliveira M.,Calhelha R.,Barros L.,Martins A.,Ferreira I.
Development of nutraceutical formulations based on the mycelium of: Pleurotus ostreatus and Agaricus bisporus
Food and Function, 8, 2155-2164, 2017

108
Svobodova B.,Barros L.,Sopik T.,Calhelha R.,Heleno S.,Alves M.,Walcott S.,Kuban V.,Ferreira I.
Non-edible parts of Solanum stramoniifolium Jacq.-a new potent source of bioactive extracts rich in phenolic compounds for functional foods
Food and Function, 8, 2013-2021, 2017

109
Jabeur I.,Martins N.,Barros L.,Calhelha R.C.,Vaz J.,Achour L.,Santos-Buelga C.,Ferreira I.C.F.R.
Contribution of the phenolic composition to the antioxidant, anti-inflammatory and antitumor potential of Equisetum giganteum L. and Tilia platyphyllos Scop.
Food and Function, 8, 975-984, 2017

110
Pereira E.,Pimenta A.,Calhelha R.,Antonio A.,Barros L.,Santos-Buelga C.,Verde S.,Ferreira I.
Infusions of gamma irradiated Aloysia citrodora L. and Mentha x piperita L.: Effects on phenolic composition, cytotoxicity, antibacterial and virucidal activities
Industrial Crops and Products, 97, 582-590, 2017

111
Sobral F.,Calhelha R.,Barros L.,Dueñas M.,Tomás A.,Santos-Buelga C.,Vilas-Boas M.,Ferreira I.
Flavonoid composition and antitumor activity of bee bread collected in Northeast Portugal
Molecules, 22, , 2017

112
Magalhães F.,Graça V.,Calhelha R.,Ferreira I.,Santos P.
Aminosquaraines as potential photodynamic agents: Synthesis and evaluation of in vitro cytotoxicity
Bioorganic and Medicinal Chemistry Letters, 27, 4467-4470, 2017

113
Maisterra M.,Castro M.Á.,Muñoz-Centeno L.M.,Calhelha R.C.,Ferreira I.C.F.R.,García P.A.
Cytotoxic Terphenyl Neolignans from Fungus Terana coerulea: New Natural Corticins D and E, and Revised Structure for Corticin A
Natural Product Communications, 12, 695-698, 2017

114
Heleno S.A.,Rudke A.R.,Calhelha R.C.,Carocho M.,Barros L.,Gonçalves O.H.,Barreiro M.F.,Ferreira I.C.F.R.
Development of dairy beverages functionalized with pure ergosterol and mycosterol extracts: An alternative to phytosterol-based beverages
Food and Function, 8, 103-110, 2017

115
Svobodova B.,Barros L.,Calhelha R.,Heleno S.,Alves M.,Walcott S.,Bittova M.,Kuban V.,Ferreira I.
Bioactive properties and phenolic profile of Momordica charantia L. medicinal plant growing wild in Trinidad and Tobago
Industrial Crops and Products, 95, 365-373, 2017

116
Rodrigues A.,Almeida B.,Rodrigues J.,Queiroz M.,Calhelha R.,Ferreira I.,Pires A.,Pereira A.,Araújo J.,Coutinho P.,Castanheira E.
Magnetoliposomes as carriers for promising antitumor thieno[3,2-b]pyridin-7-arylamines: photophysical and biological studies
RSC Advances, 7, 15352-15361, 2017

117
Jabeur I.,Tobaldini F.,Martins N.,Barros L.,Martins I.,Calhelha R.C.,Henriques M.,Silva S.,Achour L.,Santos-Buelga C.,Ferreira I.C.F.R.
Bioactive properties and functional constituents of Hypericum androsaemum L.: A focus on the phenolic profile
Food Research International, 89, 422-431, 2016

118
Ferreira D.,Conceição D.,Calhelha R.,Sousa T.,Socoteanu R.,Ferreira I.,Vieira Ferreira L.
Porphyrin dye into biopolymeric chitosan films for localized photodynamic therapy of cancer
Carbohydrate Polymers, 151, 160-171, 2016

119
Taofiq O.,Heleno S.A.,Calhelha R.C.,Alves M.J.,Barros L.,Barreiro M.F.,González-Paramás A.M.,Ferreira I.C.F.R.
Development of Mushroom-Based cosmeceutical formulations with Anti-Inflammatory, Anti-Tyrosinase, antioxidant, and antibacterial properties
Molecules, 21, , 2016

120
Ribeiro A.,Barros L.,Calhelha R.C.,Carocho M.,Ćirić A.,Sokovic M.,Dias M.M.,Santos-Buelga C.,Barreiro M.F.,Ferreira I.C.F.R.
Tarragon phenolic extract as a functional ingredient for pizza dough: Comparative performance with ascorbic acid (E300)
Journal of Functional Foods, 26, 268-278, 2016

121
Carocho M.,Barros L.,Barreira J.,Calhelha R.,Soković M.,Fernández-Ruiz V.,Buelga C.,Morales P.,Ferreira I.
Basil as functional and preserving ingredient in "serra da Estrela" cheese
Food Chemistry, 207, 51-59, 2016

122
Graça V.,Barros L.,Calhelha R.,Dias M.,Carvalho A.,Santos-Buelga C.,Santos P.,Ferreira I.
Chemical characterization and bioactive properties of aqueous and organic extracts of Geranium robertianum L.
Food and Function, 7, 3807-3814, 2016

123
Fotopoulou T.,Ćirić A.,Kritsi E.,Calhelha R.,Ferreira I.,Soković M.,Zoumpoulakis P.,Koufaki M.
Antimicrobial/Antibiofilm Activity and Cytotoxic Studies of β-Thujaplicin Derivatives
Archiv der Pharmazie, 698-709, 2016

124
Pereira E.,Pimenta A.,Calhelha R.,Antonio A.,Verde S.,Barros L.,Santos-Buelga C.,Ferreira I.
Effects of gamma irradiation on cytotoxicity and phenolic compounds of Thymus vulgaris L. and Mentha x piperita L.
LWT - Food Science and Technology, 71, 370-377, 2016

125
Sobral F.,Sampaio A.,Falcão S.,Queiroz M.,Calhelha R.,Vilas-Boas M.,Ferreira I.
Chemical characterization, antioxidant, anti-inflammatory and cytotoxic properties of bee venom collected in Northeast Portugal
Food and Chemical Toxicology, 94, 172-177, 2016

126
Miguel M.,Barros L.,Pereira C.,Calhelha R.,Garcia P.,Castro M.,Santos-Buelga C.,Ferreira I.
Chemical characterization and bioactive properties of two aromatic plants:: Calendula officinalis L. (flowers) and Mentha cervina L. (leaves)
Food and Function, 7, 2223-2232, 2016

127
Graça V.,Barros L.,Calhelha R.,Dias M.,Carvalho A.,Santos-Buelga C.,Ferreira I.,Santos P.
Chemical characterization and bioactive properties of: Geranium molle L.: From the plant to the most active extract and its phytochemicals
Food and Function, 7, 2204-2212, 2016

128
Chahdoura H.,Barreira J.C.M.,Fernández-Ruiz V.,Morales P.,Calhelha R.C.,Flamini G.,Soković M.,Ferreira I.C.F.R.,Achour L.
Bioactivity, proximate, mineral and volatile profiles along the flowering stages of Opuntia microdasys (Lehm.): Defining potential applications
Food and Function, 7, 1458-1467, 2016

129
Ferreira D.,Conceição D.,Fernandes F.,Sousa T.,Calhelha R.,Ferreira I.,Santos P.,Vieira Ferreira L.
Characterization of a Squaraine/Chitosan System for Photodynamic Therapy of Cancer
Journal of Physical Chemistry B, 120, 1212-1220, 2016

130
Raposo C.D.,Petrova K.T.,Barros M.T.,Calhelha R.C.,Sokovi M.,Ferreira I.C.F.R.
Synthesis, characterization, antimicrobial and antitumor activities of sucrose Octa(N-ethyl)carbamate
Medicinal Chemistry, 12, 22-29, 2016

131
Liberal Â.,Calhelha R.,Pereira C.,Adega F.,Barros L.,Dueñas M.,Santos-Buelga C.,Abreu R.,Ferreira I.
A comparison of the bioactivity and phytochemical profile of three different cultivars of globe amaranth: Red, white, and pink
Food and Function, 7, 679-688, 2016

132
Guimarães R.,Calhelha R.,Froufe H.,Abreu R.,Carvalho A.,Queiroz M.,Ferreira I.
Wild Roman chamomile extracts and phenolic compounds: Enzymatic assays and molecular modelling studies with VEGFR-2 tyrosine kinase
Food and Function, 7, 79-83, 2016

133
Valles E.,García P.,Miguel Del Corral J.,Pérez M.,Ferreira I.,Calhelha R.,San Feliciano A.,Castro M.
Synthesis and cytotoxic evaluation of new terpenylpurines
RSC Advances, 6, 105412-105420, 2016

134
Rached W.,Calhelha R.,Fernandes Â.,Carvalho A.,Bennaceur M.,Marouf A.,Barros L.,Santos-Buelga C.,Ferreira I.
Phytochemical characterization and bioactive properties of Osyris quadripartita Salzm. ex Decne. leaves from Algeria
RSC Advances, 6, 72768-72776, 2016

135
Ziani B.,Calhelha R.,Barreira J.,Barros L.,Hazzit M.,Ferreira I.
Bioactive properties of medicinal plants from the Algerian flora: Selecting the species with the highest potential in view of application purposes
Industrial Crops and Products, 77, 582-589, 2015

136
Pires T.,Dias M.,Calhelha R.,Carvalho A.,Queiroz M.,Barros L.,Ferreira I.,McPhee D.
Bioactive properties of tabebuia impetiginosa-based phytopreparations and phytoformulations: A comparison between extracts and dietary supplements
Molecules, 20, 22863-22871, 2015

137
Souza A.,Corrêa R.,Barros L.,Calhelha R.,Santos-Buelga C.,Peralta R.,Bracht A.,Matsushita M.,Ferreira I.
Phytochemicals and bioactive properties of Ilex paraguariensis: An in-vitro comparative study between the whole plant, leaves and stems
Food Research International, 78, 286-294, 2015

138
Petrova K.,Potewar T.,Correia-Da-Silva P.,Barros M.,Calhelha R.,Ćiric A.,Soković M.,Ferreira I.
Antimicrobial and cytotoxic activities of 1,2,3-triazole-sucrose derivatives
Carbohydrate Research, 417, 66-71, 2015

139
Taofiq O.,Calhelha R.,Heleno S.,Barros L.,Martins A.,Santos-Buelga C.,Queiroz M.,Ferreira I.
The contribution of phenolic acids to the anti-inflammatory activity of mushrooms: Screening in phenolic extracts, individual parent molecules and synthesized glucuronated and methylated derivatives
Food Research International, 76, 821-827, 2015

140
Machado V.A.,Peixoto D.,Costa R.,Froufe H.J.C.,Calhelha R.C.,Abreu R.M.V.,Ferreira I.C.F.R.,Soares R.,Queiroz M.J.R.P.
Synthesis, antiangiogenesis evaluation and molecular docking studies of 1-aryl-3-[(thieno[3,2-b]pyridin-7-ylthio)phenyl]ureas: Discovery of a new substitution pattern for type II VEGFR-2 Tyr kinase inhibitors
Bioorganic and Medicinal Chemistry, 23, 6497-6509, 2015

141
Bastos C.,Barros L.,Dueñas M.,Calhelha R.C.,Queiroz M.J.R.P.,Santos-Buelga C.,Ferreira I.C.F.R.
Chemical characterisation and bioactive properties of Prunus avium L.: The widely studied fruits and the unexplored stems
Food Chemistry, 173, 1045-1053, 2015

142
Glamočlija J.,Ćirić A.,Nikolić M.,Fernandes Â.,Barros L.,Calhelha R.,Ferreira I.,Soković M.,Van Griensven L.
Chemical characterization and biological activity of Chaga (Inonotus obliquus), a medicinal "mushroom"
Journal of Ethnopharmacology, 162, 323-332, 2015

143
Barros L.,Calhelha R.C.,Queiroz M.J.R.P.,Santos-Buelga C.,Santos E.A.,Regis W.C.B.,Ferreira I.C.F.R.
The powerful in vitro bioactivity of Euterpe oleracea Mart. seeds and related phenolic compounds
Industrial Crops and Products, 76, 318-322, 2015

144
Carocho M.,Barros L.,Calhelha R.,Ćirić A.,Soković M.,Santos-Buelga C.,Morales P.,Ferreira I.
Melissa officinalis L. decoctions as functional beverages: A bioactive approach and chemical characterization
Food and Function, 6, 2240-2248, 2015

145
Pereira C.,Barreira J.,Calhelha R.,Lopes M.,Queiroz M.,Vilas-Boas M.,Barros L.,Ferreira I.
Is honey able to potentiate the antioxidant and cytotoxic properties of medicinal plants consumed as infusions for hepatoprotective effects?
Food and Function, 6, 1435-1442, 2015

146
Corrêa R.C.G.,De Souza A.H.P.,Calhelha R.C.,Barros L.,Glamoclija J.,Sokovic M.,Peralta R.M.,Bracht A.,Ferreira I.C.F.R.
Bioactive formulations prepared from fruiting bodies and submerged culture mycelia of the Brazilian edible mushroom Pleurotus ostreatoroseus Singer
Food and Function, 6, 2155-2164, 2015

147
Costa C.N.C.,Hortelão A.C.L.,Ramos J.M.F.,Oliveira A.D.S.,Calhelha R.C.,Queiroz M.J.R.P.,Coutinho P.J.G.,Castanheira E.M.S.
A new antitumoral Heteroarylaminothieno[3,2-b]pyridine derivative: Its incorporation into liposomes and interaction with proteins monitored by fluorescence
Photochemical and Photobiological Sciences, 13, 1730-1740, 2014

148
Rodrigues A.,Carvalho M.,Cardoso J.,Calhelha R.,Queiroz M.,Coutinho P.,Castanheira E.
Benzothienoquinolines: New one-pot synthesis and fluorescence studies of their interaction with DNA and polynucleotides
Journal of Photochemistry and Photobiology A: Chemistry, 294, 20-30, 2014

149
Pereira E.,Barros L.,Calhelha R.,Dueñas M.,Carvalho A.,Santos-Buelga C.,Ferreira I.
Bioactxf Arenaria montana L
Food and Function, 5, 1848-1855, 2014

150
Guimarães R.,Barros L.,Calhelha R.,Carvalho A.,Queiroz M.,Ferreira I.
Bioactivity of Different Enriched Phenolic Extracts of Wild Fruits from Northeastern Portugal: A Comparative Study
Plant Foods for Human Nutrition, 69, 37-42, 2014

151
Stojković D.,Barros L.,Calhelha R.,Glamočlija J.,Ćirić A.,Van Griensven L.,Soković M.,Ferreira I.
A detailed comparative study between chemical and bioactive properties of Ganoderma lucidum from different origins
International Journal of Food Sciences and Nutrition, 65, 42-47, 2014

152
Calhelha R.,Falcão S.,Queiroz M.,Vilas-Boas M.,Ferreira I.
Cytotoxicity of portuguese propolis: The proximity of the in vitro doses for tumor and normal cell lines
BioMed Research International, 2014, , 2014

153
Calhelha R.,Peixoto D.,Vilas Boas M.,Queiroz M.,Ferreira I.
Antioxidant activity of aminodiarylamines in the thieno[3,2-b]pyridine series: Radical scavenging activity, lipid peroxidation inhibition and redox profile
Journal of Enzyme Inhibition and Medicinal Chemistry, 29, 311-316, 2014

154
Pereira C.,Calhelha R.,Barros L.,Queiroz M.,Ferreira I.
Synergisms in antioxidant and anti-hepatocellular carcinoma activities of artichoke, milk thistle and borututu syrups
Industrial Crops and Products, 52, 709-713, 2014

155
Pereira C.,Calhelha R.,Antonio A.,Queiroz M.,Barros L.,Ferreira I.
Effects of gamma radiation on chemical and antioxidant properties, anti-hepatocellular carcinoma activity and hepatotoxicity of borututu
Innovative Food Science and Emerging Technologies, 26, 271-277, 2014

156
157
Rashed K.,Ćirić A.,Glamočlija J.,Calhelha R.,Ferreira I.,Soković M.
Antimicrobial and cytotoxic activities of Alnus rugosa L. aerial parts and identification of the bioactive components
Industrial Crops and Products, 59, 189-196, 2014

158
Faustino V.,Pinho D.,Yaginuma T.,Calhelha R.,Ferreira I.,Lima R.
Extensional flow-based microfluidic device: Deformability assessment of red blood cells in contact with tumor cells
Biochip Journal, 8, 42-47, 2014

159
Heleno S.,Ferreira I.,Calhelha R.,Esteves A.,Martins A.,Queiroz M.
Cytotoxicity of Coprinopsis atramentaria extract, organic acids and their synthesized methylated and glucuronate derivatives
Food Research International, 55, 170-175, 2014

160
Carocho M.,Calhelha R.,Queiroz M.,Bento A.,Morales P.,Soković M.,Ferreira I.
Infusions and decoctions of Castanea sativa flowers as effective antitumor and antimicrobial matrices
Industrial Crops and Products, 62, 42-46, 2014

161
Dias M.,Barreira J.,Calhelha R.,Queiroz M.,Oliveira M.,Soković M.,Ferreira I.
Two-dimensional PCA highlights the differentiated antitumor and antimicrobial activity of methanolic and aqueous extracts of Laurus nobilis L. from different origins
BioMed Research International, 2014, , 2014

162
Reis F.,Barreira J.,Calhelha R.,van Griensven L.,Ćirić A.,Glamočlija J.,Soković M.,Ferreira I.
Chemical characterization of the medicinal mushroom Phellinus linteus (Berkeley & Curtis) Teng and contribution of different fractions to its bioactivity
LWT - Food Science and Technology, 58, 478-485, 2014

163
Faustino V.,Pinho D.,Yaginuma T.,Calhelha R.,Kim G.,Arana S.,Ferreira I.,Oliveira M.,Lima R.
Flow of red blood cells suspensions through hyperbolic microcontractions
Lecture Notes in Computational Vision and Biomechanics, 12, 151-163, 2014

164
Nikolić M.,Glamočlija J.,Ferreira I.C.F.R.,Calhelha R.C.,Fernandes A.,Marković T.,Marković D.,Giweli A.,Soković M.
Chemical composition, antimicrobial, antioxidant and antitumor activity of Thymus serpyllum L., Thymus algeriensis Boiss. and Reut and Thymus vulgaris L. essential oils
Industrial Crops and Products, 52, 183-190, 2014

165
Reis F.,Barros L.,Calhelha R.,Ćirić A.,van Griensven L.,Soković M.,Ferreira I.
The methanolic extract of Cordyceps militaris (L.) Link fruiting body shows antioxidant, antibacterial, antifungal and antihuman tumor cell lines properties
Food and Chemical Toxicology, 62, 91-98, 2013

166
Santos A.,Barros L.,Calhelha R.,Dueñas M.,Carvalho A.,Santos-Buelga C.,Ferreira I.
Leaves and decoction of Juglans regia L.: Different performances regarding bioactive compounds and in vitro antioxidant and antitumor effects
Industrial Crops and Products, 51, 430-436, 2013

167
Queiroz M.,Peixoto D.,Calhelha R.,Soares P.,Dos Santos T.,Lima R.,Campos J.,Abreu R.,Ferreira I.,Vasconcelos M.
New di(hetero)arylethers and di(hetero)arylamines in the thieno[3,2-b]pyridine series: Synthesis, growth inhibitory activity on human tumor cell lines and non-tumor cells, effects on cell cycle and on programmed cell death
European Journal of Medicinal Chemistry, 69, 855-862, 2013

168
Barros L.,Pereira E.,Calhelha R.,Dueñas M.,Carvalho A.,Santos-Buelga C.,Ferreira I.
Bioactivity and chemical characterization in hydrophilic and lipophilic compounds of Chenopodium ambrosioides L.
Journal of Functional Foods, 5, 1732-1740, 2013

169
Soares P.,Costa R.,Froufe H.J.C.,Calhelha R.C.,Peixoto D.,Ferreira I.C.F.R.,Abreu R.M.V.,Soares R.,Queiroz M.J.R.P.
1-aryl-3-[4-(thieno[3,2-d]pyrimidin-4-yloxy)phenyl]ureas as VEGFR-2 tyrosine kinase inhibitors: Synthesis, biological evaluation, and molecular modelling studies
BioMed Research International, 2013, , 2013

170
Pereira C.,Calhelha R.,Barros L.,Ferreira I.
Antioxidant properties, anti-hepatocellular carcinoma activity and hepatotoxicity of artichoke, milk thistle and borututu
Industrial Crops and Products, 49, 61-65, 2013

171
Santos T.,Tavares C.,Sousa D.,Vaz J.,Calhelha R.,Martins A.,Almeida G.,Ferreira I.,Vasconcelos M.
Suillus luteus methanolic extract inhibits cell growth and proliferation of a colon cancer cell line
Food Research International, 53, 476-481, 2013

172
Guimarães R.,Barros L.,Dueñas M.,Calhelha R.,Carvalho A.,Santos-Buelga C.,Queiroz M.,Ferreira I.
Infusion and decoction of wild German chamomile: Bioactivity and characterization of organic acids and phenolic compounds
Food Chemistry, 136, 947-954, 2013

173
Guimarães R.,Barros L.,Dueñas M.,Calhelha R.,Carvalho A.,Santos-Buelga C.,Queiroz M.,Ferreira I.
Nutrients, phytochemicals and bioactivity of wild Roman chamomile: A comparison between the herb and its preparations
Food Chemistry, 136, 718-725, 2013

174
175
Carvalho M.,Hortelao A.,Calhelha R.,Abreu A.,Coutinho P.,Queiroz M.,Castanheir E.
Fluorescence studies on potential antitumor 6-(hetero)arylthieno[3,2-b] pyridine derivatives in solution and in nanoliposomes
Journal of Photochemistry and Photobiology A: Chemistry, 264, 56-66, 2013

176
Rodrigues S.,Calhelha R.,Barreira J.,Dueñas M.,Carvalho A.,Abreu R.,Santos-Buelga C.,Ferreira I.
Crataegus monogyna buds and fruits phenolic extracts: Growth inhibitory activity on human tumor cell lines and chemical characterization by HPLC-DAD-ESI/MS
Food Research International, 49, 516-523, 2012

177
Calhelha R.,Ferreira I.,Peixoto D.,Abreu R.,Vale-Silva L.,Pinto E.,Lima R.,Alvelos M.,Vasconcelos M.,Queiroz M.
Aminodi(hetero)arylamines in the thieno[3,2-b]pyridine series: Synthesis, effects in human tumor cells growth, cell cycle analysis, apoptosis and evaluation of toxicity using non-tumor cells
Molecules, 17, 3834-3843, 2012

178
Castanheira E.,Carvalho M.,Rodrigues A.,Calhelha R.,Queiroz M.
New potential antitumoral fluorescent tetracyclic thieno[3,2-b]pyridine derivatives: Interaction with DNA and nanosized liposomes
Nanoscale Research Letters, 6, 1-8, 2011

179
Abreu R.,Ferreira I.,Calhelha R.,Lima R.,Vasconcelos M.,Adega F.,Chaves R.,Queiroz M.
Anti-hepatocellular carcinoma activity using human HepG2 cells and hepatotoxicity of 6-substituted methyl 3-aminothieno[3,2-b]pyridine-2- carboxylate derivatives: In vitro evaluation, cell cycle analysis and QSAR studies
European Journal of Medicinal Chemistry, 46, 5800-5806, 2011

180
Castanheira E.,Carvalho M.,Soares D.,Coutinho P.,Calhelha R.,Queiroz M.
Fluorescence studies on new potential antitumoral benzothienopyran-1-ones in solution and in liposomes
Journal of Fluorescence, 21, 911-922, 2011

181
182
Queiroz M.,Calhelha R.,Vale-Silva L.,Pinto E.,São-José Nascimento M.
Novel 6-[(hetero)arylamino]thieno[3,2-b]pyridines: Synthesis and antitumoral activities
European Journal of Medicinal Chemistry, 45, 5732-5738, 2010

183
Queiroz M.,Calhelha R.,Vale-Silva L.,Pinto E.,Lima R.,Vasconcelos M.
Efficient synthesis of 6-(hetero)arylthieno[3,2-b]pyridines by Suzuki-Miyaura coupling. Evaluation of growth inhibition on human tumor cell lines, SARs and effects on the cell cycle
European Journal of Medicinal Chemistry, 45, 5628-5634, 2010

184
Silva J.,Machado V.,Calhelha R.,Queiroz M.,Coutinho O.
Di(hetero)arylamines in the benzo[b]thiophene series as novel potent antioxidants
Drug discoveries & therapeutics, 4, 246-256, 2010

185
186
Queiroz M.,Calhelha R.,Vale-Silva L.,Pinto E.,São-José Nascimento M.
Synthesis of novel 3-(aryl)benzothieno[2,3-c]pyran-1-ones from Sonogashira products and intramolecular cyclization: Antitumoral activity evaluation
European Journal of Medicinal Chemistry, 44, 1893-1899, 2009

187
Abreu R.,Falcão S.,Calhelha R.,Ferreira I.,Queiroz M.,Vilas-Boas M.
Insights in the antioxidant activity of diarylamines from the 2,3-dimethylbenzo[b]thiophene through the redox profile
Journal of Electroanalytical Chemistry, 628, 43-47, 2009

188
189
190
Barros L.,Calhelha R.,Vaz J.,Ferreira I.,Baptista P.,Estevinho L.
Antimicrobial activity and bioactive compounds of Portuguese wild edible mushrooms methanolic extracts
European Food Research and Technology, 225, 151-156, 2007

191
192
Sousa A.,Ferreira I.C.F.R.,Calhelha R.,Andrade P.B.,Valentão P.,Seabra R.,Estevinho L.,Bento A.,Pereira J.A.
Phenolics and antimicrobial activity of traditional stoned table olives 'alcaparra'
Bioorganic and Medicinal Chemistry, 14, 8533-8538, 2006

193
Queiroz M.,Ferreira I.,Gaetano Y.,Kirsch G.,Calhelha R.,Estevinho L.
Synthesis and antimicrobial activity studies of ortho-chlorodiarylamines and heteroaromatic tetracyclic systems in the benzo[b]thiophene series
Bioorganic and Medicinal Chemistry, 14, 6827-6831, 2006

194
Calhelha R.,Andrade J.,Ferreira I.,Estevinho L.
Toxicity effects of fungicide residues on the wine-producing process
Food Microbiology, 23, 393-398, 2006

195
196
Abreu A.,Ferreira P.,Monteiro L.,Queiroz M.,Ferreira I.,Calhelha R.,Estevinho L.
Synthesis of pure stereoisomers of benzo[b]thienyl dehydrophenylalanines by Suzuki cross-coupling. Preliminary studies of antimicrobial activity
Tetrahedron, 60, 11821-11828, 2004

197
Ferreira I.,Calhelha R.,Estevinho L.,Queiroz M.
Screening of antimicrobial activity of diarylamines in the 2,3,5-trimethylbenzo[b]thiophene series: A structure-activity evaluation study
Bioorganic and Medicinal Chemistry Letters, 14, 5831-5833, 2004

198
Queiroz M.,Begouin A.,Ferreira I.,Kirsch G.,Calhelha R.,Barbosa S.,Estevinho L.
Palladium-catalysed amination of electron-deficient or relatively electron-rich benzo[b]thienyl bromides - Preliminary studies of antimicrobial activity and SARs
European Journal of Organic Chemistry, 3679-3685, 2004

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